GPR161 Polyclonal Antibody, PE-Cy5 Conjugated, PE/Cy5, Rabbit

Produktübersicht

• Artikelname: GPR161 Polyclonal Antibody, PE-Cy5 Conjugated, PE/Cy5, Rabbit
• Artikelnummer: BSS-BS-15385R-PE-CY5
• Hersteller Artikelnummer: bs-15385R-PE-Cy5
• Alternativnummer: BSS-BS-15385R-PE-CY5-100
• Hersteller: Bioss
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human
• Konjugation: PE/Cy5
• Alternative Synonym: RE2, G-protein coupled receptor 161, G-protein coupled receptor RE2, GPR161

Produktbeschreibung

Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 1ug/ul
• NCBI: 23432
• UniProt: Q8N6U8
• Puffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Quelle: KLH conjugated synthetic peptide derived from human GPR161
• Target-Kategorie: GPR161

Anwendungsbeschreibung

• Application Verdünnung: WB(1:300-5000)