KSR1 (phospho S404), p-KSR1 (phospho S404), BKSR 1, BKSR1, dKsr, EK 31, EK31, hb, Kinase suppressor of Ras 1, Kinase suppressor of ras, KSR 1, KSR, KSR1, KSR1_HUMAN, Positive Ras signaling mediator family member (86.4 kD), Positive Ras signaling mediator family member, RSU 2, RSU2, SR 31, SR31, Suppressor of activated let 60 Ras SUR3, Suppressor of Ras1 31.
KSR1 is a molecular scaffold and positive regulator of the Raf/MEK/ERK phosphorylation cascade. It was initially considered to be a protein kinase acting in the Ras pathway. KSR1 is required for maximal ERK activation induced by growth factors and by some cytotoxic agents. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane associated.
