A130009K11Rik, DKFZp667O116, E3 ubiquitin-protein ligase TRIM56, FLJ35608, Gm452, MGC37358, OTTMUSP00000027392, RING finger protein 109, RNF109, TRI56_HUMAN, Trim56, Tripartite motif containing protein 56, Tripartite motif-containing protein 56.
E3 ubiquitin-protein ligase that mediates Lys-63-linked polyubiquitination of TMEM173/STING, thereby playing a key role in innate immunity. TMEM173/STING Lys-63-linked ubiquitination activates the production of type I interferon IFN-beta following detection of pathogen- and host-derived double-stranded DNA (By similarity).