UV2, COFS4, RAD1, DNA excision repair protein ERCC-1, ERCC1
Isoform 1: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.
