HIF-1-alpha, hypoxia-inducible factor 1, alpha subunit isoform 1, Hypoxia-inducible factor 1 alpha, HIF-1 alpha, HIF1 alpha, HIF-1a, HIF-1alpha, ARNT-interacting protein, Member of PAS protein1, Basic-helix-loop-helix-PAS protein MOP1, Hypoxia-inducible factor -1 Alpha.
Functions as a master transcriptional regulator of theadaptive response to hypoxia. Under hypoxic conditions activatesthe transcription of over 40 genes, including, erythropoietin,glucose transporters, glycolytic enzymes, vascular endothelialgrowth factor, and other genes whose protein products increaseoxygen delivery or facilitate metabolic adaptation to hypoxia.Plays an essential role in embryonic vascularization, tumorangiogenesis and pathophysiology of ischemic disease. Binds to coreDNA sequence 5-[AG]CGTG-3 within the hypoxia response element(HRE) of target gene promoters. Activation requires recruitment oftranscriptional coactivators such as CREBPB and EP300. Activity isenhanced by interaction with both, NCOA1 or NCOA2. Interaction withredox regulatory protein APEX seems to activate CTAD andpotentiates activation by NCOA1 and CREBBP.
