Serine protease HTRA2, mitochondrial, HTRA2, High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine protease 25 Serine proteinase OMI, HTRA2, OMI, PRSS25
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
