Antibody deficiency due to defect in CD19, included, AW495831, B lymphocyte antigen CD19, B lymphocyte surface antigen B4, B4, CD 19, CD19 antigen, CD19 molecule, Cd19 protein, Differentiation Antigen CD19, Leu 12, Leu12, Lymphocyte Surface Antigen, MGC109570, MGC12802, T-cell surface antigen Leu-12.
CD19 is a transmembrane glycoprotein that is delectively expressed on the cell surface of B-lymphocytes,where it activates intracellular signaling cascades involving both Ras and phosphatidylinositol 3-kinase pathways.Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
