AW105885, E3 ubiquitin protein ligase Topors, E3 ubiquitin-protein ligase Topors, LUN, p53 binding protein 3, p53 BP3/LUN, p53-binding protein 3, p53BP3, p53BP3/LUN, Retinitis pigmentosa 31, RP31, SUMO1 protein E3 ligase Topors, SUMO1-protein E3 ligase Topors, Topoisomerase I binding arginine/serine rich, Topoisomerase I binding arginine/serine rich protein, Topoisomerase I binding protein, Topoisomerase I binding RING finger protein, Topoisomerase I-binding arginine/serine-rich protein, Topoisomerase I-binding RING finger protein, Topoisomerase I-binding RS protein, TOPORS, TOPRS_HUMAN, TP53BPL, Tumor protein p53 binding protein, Tumor suppressor p53 binding protein 3, Tumor suppressor p53-binding protein 3.
Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
