CDKN1A/p21 Polyclonal Antibody, HRP Conjugated, Rabbit
Artikelnummer:
BSS-BS-22795R-HRP
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| Artikelname: | CDKN1A/p21 Polyclonal Antibody, HRP Conjugated, Rabbit |
| Artikelnummer: | BSS-BS-22795R-HRP |
| Hersteller Artikelnummer: | bs-22795R-HRP |
| Alternativnummer: | BSS-BS-22795R-HRP-100 |
| Hersteller: | Bioss |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | IHC-Fr, IHC-P |
| Spezies Reaktivität: | Human, Mouse, Rat |
| Konjugation: | HRP |
| Alternative Synonym: | p21, P21 protein, Activating Fragment 1, CAP20, Cation chloride cotransporter-interacting protein 1, CDK Interacting Protein 1, CDK-interacting protein 1, CDKI, CDKN 1, CDKN1, CDKN1A, CIP1, Cyclin Dependent Kinase Inhibitor 1A, Cyclin-dependent kinase inhibitor 1, Cyclin-dependent kinase inhibitor 1A (P21), Cyclin-dependent kinase inhibitor 1A (p21, Cip1), DNA Synthesis Inhibitor, MDA 6, MDA-6, MDA6, Melanoma Differentiation Associated Protein 6, Melanoma differentiation-associated protein 6, Melanoma differentiation-associated protein, p21CIP1, p21WAF, PIC1, SDI1, SLC12A9, WAF1, Wildtype p53 Activating Fragment 1, Wildtype p53-activated fragment 1, CDN1A_HUMAN. |
| May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. |
| Application Verdünnung: | IHC-P(IHC-P=1:100-500), IHC-F(IHC-F=1:100-500) |
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