DHAND 2, dHAND, DHAND2, Ehand 2, Ehand2, FLJ16260, HAND 2, Hand2, autonomic nervous system and neural crest derivatives-expressed protein 2, heart, Basic helix loop helix transcription factor HAND2, bHLHa26, Class A basic helix-loop-helix protein 26, Deciduum, Deciduum heart autonomic nervous system and neural crest derivatives expressed protein 2 antibody HAND2_HUMAN, Heart and neural crest derivatives expressed 2, Heart and neural crest derivatives expressed protein 2, heart and neural crest derivatives expressed transcript 2, Heart- and neural crest derivatives-expressed protein 2, Hed, Highly similar to dHAND M musculus, MGC125303, MGC125304, Th 2, Th2, Thing 2, Thing2.
Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5-CANNTG-3 (By similarity).
