Amphoterin, High mobility group 1, High Mobility Group Box 1, High mobility group protein 1, High mobility group protein B1, HMG3, HMGB 1,HMGB-1, Hmgb1 protein, Nonhistone chromosomal protein HMG1, SBP 1, SBP-1, Sulfoglucuronyl carbohydrate binding protein, HMGB1_HUMAN.
High Mobility Group Box-1 (HMGB1) is a cytokine implicated in the pathogenesis of rheumatoid arthritis (RA) and other inflammatory diseases. The cholinergic anti-inflammatory pathway, a vagus nerve dependent mechanism, inhibits HMGB1 release in experimental disease models Function : DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. Subunit : Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2.
