DIF-3, DIF3, FLJ21230, FLJ22561, Gametogenetin-binding protein 2, GGNB2_HUMAN, Ggnbp2, Laryngeal carcinoma-related protein 1, LCRG1, LZK1, Protein ZNF403, ZFP403, ZNF403.
LCRG1 is a 697 amino acid protein that may be involved in spermatogenesis. LCRG1 interacts with gametogenetin, a protein primarily expressed in testis and ovary. Localized in the cytoplasm, LCRG associates with vesicular structures. LCRG1 is expressed in brain, placenta, lung, liver and kidney, with highest levels found in heart, pancreas and skeletal muscle. LCRG1 is strongly down-regulated in 40% of primary laryngeal carcinoma and in 6 of 10 various cancer cell lines. Phosphorylated on Serine 360, LCRG1 exists as three isoforms produced by alternative splicing events.
