Phospho-LRP6 (Ser1490) Polyclonal Antibody, PE Conjugated, Rabbit
Artikelnummer:
BSS-BS-3253R-PE
Hersteller Artikelnummer:
bs-3253R-PE
Alternativnummer:
BSS-BS-3253R-PE-100
Hersteller:
Bioss
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IF, WB
Spezies Reaktivität:
Human, Rat
Konjugation:
PE
Alternative Synonym:
ADCAD2, Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
