Phospho-NF2 (Ser518) Polyclonal Antibody, PerCP Conjugated, Rabbit

Produktübersicht

• Artikelname: Phospho-NF2 (Ser518) Polyclonal Antibody, PerCP Conjugated, Rabbit
• Artikelnummer: BSS-BS-3291R-PERCP
• Hersteller Artikelnummer: bs-3291R-PerCP
• Alternativnummer: BSS-BS-3291R-PERCP-100
• Hersteller: Bioss
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IF, WB
• Spezies Reaktivität: Mouse, Rat
• Konjugation: PerCP
• Alternative Synonym: ACN, SCH, BANF, Merlin, Moesin-ezrin-radixin-like protein, Neurofibromin-2, Schwannomerlin, Schwannomin, NF2

Produktbeschreibung

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 1ug/ul
• NCBI: 4771
• UniProt: P35240
• Puffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Quelle: KLH conjugated synthetic phosphopeptide derived from human Merlin around the phosphorylation site of Ser518
• Target-Kategorie: Phospho-NF2 (Ser518)

Anwendungsbeschreibung

• Application Verdünnung: WB(1:300-5000), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)