KEAP1 Polyclonal Antibody, PE-Cy7 Conjugated, PE/Cy7, Rabbit

Produktübersicht

• Artikelname: KEAP1 Polyclonal Antibody, PE-Cy7 Conjugated, PE/Cy7, Rabbit
• Artikelnummer: BSS-BS-3648R-PE-CY7
• Hersteller Artikelnummer: bs-3648R-PE-Cy7
• Alternativnummer: BSS-BS-3648R-PE-CY7-100
• Hersteller: Bioss
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human, Mouse, Rat
• Konjugation: PE/Cy7
• Alternative Synonym: INrf2, KLHL19, Kelch-like ECH-associated protein 1, Cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, KIAA0132

Produktbeschreibung

Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 1ug/ul
• NCBI: 9817
• UniProt: Q14145
• Puffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Quelle: KLH conjugated synthetic peptide derived from human KEAP1
• Target-Kategorie: KEAP1

Anwendungsbeschreibung

• Application Verdünnung: WB(1:300-5000)