ACL, ATP citrate pro-S lyase, ATP citrate synthase, Citrate cleavage enzyme, EC 2.3.3.8, A730098H14RIK, ACLY, ATP CITRATE LYASE, ATPCL, AW538652, Cce, CITRATE LYASE, CLATP, MGC124629.
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
