PLCL1, PLCE, Phospholipase C deleted in lung carcinoma, Phospholipase C epsilon, Phospholipase C like 1, Phospholipase C related but catalytically inactive protein, Phospholipase C related, but catalytically inactive protein, PLCE, PLCL, PRIP, Plcl1, C230017K02Rik, KIAA1092, PLC-L, PLC-L1, PLCE, PLCL, PRIP, PRIP-1, PLCL1_HUMAN.
PLCL1 is involved an inositol phospholipid based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and sphatidylinositol. Component in the dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.
