Recombinant human EPOR protein, C-His (HEK293), Unconjugated

Produktübersicht

• Artikelname: Recombinant human EPOR protein, C-His (HEK293), Unconjugated
• Artikelnummer: BSS-BS-43588P
• Hersteller Artikelnummer: bs-43588P
• Alternativnummer: BSS-BS-43588P-20,BSS-BS-43588P-100,BSS-BS-43588P-500
• Hersteller: Bioss
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Other
• Konjugation: Unconjugated

Produktbeschreibung

The erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: EPOR-F (full length), EPOR-S (soluble form), and EPOR-T (truncated form). Upon erythropoietin (EPO) binding, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to have a role in erythroid cell survival. Defects in the EPOR may produce erythroleukemia and familial erythrocytosis. A functional EPOR is found in the cardiovascular system, including endothelial cells and cardiomyocytes, and data suggest that the EPO/EPO receptor system plays an important role in cardiac function. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis.

Produkteigenschaften

• Tag: C-His
• NCBI: 2057
• UniProt: P19235
• Puffer: 0.01M TBS(pH7.4)
• Quelle: Recombinant human EPOR protein is expressed in HEK293 cell with C-His. It contains the amino acid sequence of 25-250/508
• Expression System: HEK293
• Reinheit: > 90% as determined by SDS- PAGE