HGL, Human giant larvae homolog, L2GL2, L2GL2_HUMAN, Lethal 2 giant larvae protein homolog 2, Lethal giant larvae homolog 2, Lethal2 giant larvae protein homolog 2, LGL2, LLGL2.
The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the proteins ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
