EAAT2, Excitatory amino acid transporter 2, Excitotoxic amino acid transporter 2, Glial high affinity glutamate transporter, GLT 1, GLT1, Glutamate aspartate transporter II, SLC1A2, Sodium dependent glutamate aspartate transporter 2, Solute carrier family 1 glial high affinity glutamate transporter member 2, Solute carrier family 1 member 2, Excitatory amino acid transporter 2, GLT-1, SLC1A2, Sodium-dependent glutamate/aspartate transporter 2, Solute carrier family 1 member 2.
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na+ ions and one proton, in parallel with the counter-transport of one K+ ion. Mediates Cl- flux that is not coupled to amino acid transport, this avoids the accumulation of negative charges due to aspartate and Na+ symport. Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate.
