Frizzled 7 Polyclonal Antibody, PE Conjugated, Rabbit
Artikelnummer:
BSS-BS-5125R-PE
Hersteller Artikelnummer:
bs-5125R-PE
Alternativnummer:
BSS-BS-5125R-PE-100
Hersteller:
Bioss
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
FC, IF, WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
PE
Alternative Synonym:
FzE3, Frizzled-7, Fz-7, hFz7, FZD7
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
