Adaptor protein FE65a2, Amyloid beta A4 precursor protein binding family B member 1, Amyloid beta A4 precursor protein binding family B, Amyloid beta A4 precursor protein binding family B member 1, Amyloid beta precursor protein binding family B member 1, APBB 1, APBB1, FE 65, Fe65 protein, MGC 9072, MGC9072, Protein Fe65, RIR, Stat like protein, Fe-65 Protein, APBB1_HUMAN.
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimers disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene products nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimers disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
