CDC4 Polyclonal Antibody, Biotin Conjugated, Rabbit

Produktübersicht

• Artikelname: CDC4 Polyclonal Antibody, Biotin Conjugated, Rabbit
• Artikelnummer: BSS-BS-5996R-BIOTIN
• Hersteller Artikelnummer: bs-5996R-Biotin
• Alternativnummer: BSS-BS-5996R-BIOTIN-100
• Hersteller: Bioss
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IHC-Fr, IHC-P
• Spezies Reaktivität: Bovine, Canine, Human, Mouse, Porcine, Rat
• Konjugation: Biotin
• Alternative Synonym: AGO, Archipelago homolog, Archipelago, Drosophila, homolog of antibody CDC4, DKFZp686F23254, F box and WD 40 domain protein 7 archipelago homolog, Drosophila, F box and WD 40 domain protein 7, F box and WD repeat domain containing 7, F box protein FBW7, F box protein FBX30, F box protein SEL10, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, F-box/WD repeat-containing protein 7, FBW6, FBW7, FBX30, FBXO30, FBXW6, FBXW7, FBXW7_HUMAN, FLJ16457, hAgo, hCdc4, Homolog of C elegans sel 10, Homolog of C.elegans sel10, SEL-10, SEL10.

Produktbeschreibung

Fbw7 is a member of the F box protein family which are characterized by an approximately 40 amino acid motif, the F box. The F box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F box), which function in phosphorylation-dependent ubiquitination. The F box proteins are divided into 3 classes: Fbws containing WD40 domains, Fbls containing leucine rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. Fbw7 belongs to the Fbws class, in addition to an F box, this protein contains 7 tandem WD40 repeats. It binds directly to cyclin E and probably targets cyclin E for ubiquitin mediated degradation. Mutations of this gene are detected in ovarian and breast cancer cell lines. Alternative splicing of this gene generates 2 transcript variants diverging at the 5 termini.

Produkteigenschaften

• Klonalität: Polyclonal
• Konzentration: 1ug/ul
• NCBI: 55294
• Puffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
• Quelle: KLH conjugated synthetic peptide derived from human FBW7
• Target-Kategorie: CDC4

Anwendungsbeschreibung

• Application Verdünnung: IHC-P(1:200-400), IHC-F(1:100-500)