OTX015 --- BET Inhibitor, CAS [[202590-98-5]], Unconjugated

Produktübersicht

• Artikelname: OTX015 --- BET Inhibitor, CAS [[202590-98-5]], Unconjugated
• Artikelnummer: BSS-BS-60193C
• Hersteller Artikelnummer: bs-60193C
• Alternativnummer: BSS-BS-60193C-10,BSS-BS-60193C-2
• Hersteller: Bioss
• Kategorie: Biochemikalien
• Konjugation: Unconjugated

Produktbeschreibung

OTX015 is a novel, highly potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3 and BRD4 with IC50 of 10-19 nM. It inhibits the growth of a variety of human cancer cell lines with IC50 ranging from 60 to 200 nM. OTX015 results in rapid down-regulation of c-MYC expression, and show the synergistic anti-proliferative effects in combination with ALK inhibitors in ALKpos ALCL cell lines. In vivo studies using OTX015 have demonstrated efficacy in a range of oncology models. OTX015 is currently in phase I clinical development for oncology indication.

Produkteigenschaften

• Puffer: Powder
• CAS Nummer: [202590-98-5]