BETP --- GLP-1R Potentiator, CAS [[1371569-69-5]], Unconjugated

Produktübersicht

• Artikelname: BETP --- GLP-1R Potentiator, CAS [[1371569-69-5]], Unconjugated
• Artikelnummer: BSS-BS-60196C
• Hersteller Artikelnummer: bs-60196C
• Alternativnummer: BSS-BS-60196C-10,BSS-BS-60196C-2
• Hersteller: Bioss
• Kategorie: Biochemikalien
• Konjugation: Unconjugated

Produktbeschreibung

BETP is positive allosteric modulator and partial agonist of the glucagon-like peptide 1 (GLP-1) receptor. It covalently modifies cysteines 347 and 438 in GLP-1R. Specificity studies have shown that it has no activity on GLP-2, GIP, PTH or glucagon receptors. BETP has been shown to potentiate GLP-1R-dependent intracellular calcium mobilization but not cAMP accumulation in response to GLP-1(7-36)NH2 in recombinant cell lines. Conversely, BETP can enhance cAMP efficacy of GLP-1(9-36)NH2 at GLP-1R but not intracellular calcium mobilization. BETP also potentiates cAMP production of the dual-acting GLP-1R/glucagon (GCG) receptor (GCGR) agonist oxyntomodulin at GLP-1R. It promotes GLP-1(9-36)NH2-mediated glucose-dependent insulin secretion in rodent and human islet preparations as well as in rodent models following intravenous administration.

Produkteigenschaften

• Puffer: Powder
• CAS Nummer: [1371569-69-5]