(S)-crizotinib --- MTH1 Inhibitor, CAS [[1374356-45-2]], Unconjugated

Produktübersicht

• Artikelname: (S)-crizotinib --- MTH1 Inhibitor, CAS [[1374356-45-2]], Unconjugated
• Artikelnummer: BSS-BS-60208C
• Hersteller Artikelnummer: bs-60208C
• Alternativnummer: BSS-BS-60208C-10,BSS-BS-60208C-2
• Hersteller: Bioss
• Kategorie: Biochemikalien
• Konjugation: Unconjugated

Produktbeschreibung

(S)-Crizotinib is a novel potent, selective and cell permeable MTH1 inhibitor with an IC50 of ~72 nM. MTH1 is a nucleotide pool sanitizing enzyme. (S)-Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition and induces an increase in DNA single-strand breaks in cancer cells. In vivo it can effectively suppress tumor growth in colon carcinoma xenograft model by once per day oral dosing. (R)-Crizotinib, which is (R)-enantiomer of the drug, is inactive against MTH1 in vitro. Loss-of-function of MTH1 impaired growth of KRAS tumor cells. (S)-Crizotinib is a useful chemical probe to further validate MTH1 as a promising novel class of anticancer target.

Produkteigenschaften

• Puffer: Powder
• CAS Nummer: [1374356-45-2]