PYZD-4409 --- Ubiquitin-activating Enzyme (E1) Inhibitor, CAS [[423148-78-1]], Unconjugated

Produktübersicht

• Artikelname: PYZD-4409 --- Ubiquitin-activating Enzyme (E1) Inhibitor, CAS [[423148-78-1]], Unconjugated
• Artikelnummer: BSS-BS-60213C
• Hersteller Artikelnummer: bs-60213C
• Alternativnummer: BSS-BS-60213C-10,BSS-BS-60213C-2
• Hersteller: Bioss
• Kategorie: Biochemikalien
• Konjugation: Unconjugated

Produktbeschreibung

PYZD-4409 is a novel potent, selective and cell permeable inhibitor of ubiquitin-activating enzyme (E1). It induces cell death in hematologic malignant cell lines and primary patient samples preferentially over normal hematopoietic cells. PYZD-4409 blocks degradation of the short-lived proteins p53 and cyclin D3. It inhibits NF-kappaB activation and induces cell death associated with ER stress. It also displays antitumor effects in a mouse model of leukemia by intraperitoneal administration of the drug.

Produkteigenschaften

• Puffer: Powder
• CAS Nummer: [423148-78-1]