NSC636819, KDM4A/KDM4B Inhibitor, CAS [[1618672-71-1]], Unconjugated

Produktübersicht

• Artikelname: NSC636819, KDM4A/KDM4B Inhibitor, CAS [[1618672-71-1]], Unconjugated
• Artikelnummer: BSS-BS-60290C
• Hersteller Artikelnummer: bs-60290C
• Alternativnummer: BSS-BS-60290C-10,BSS-BS-60290C-2
• Hersteller: Bioss
• Kategorie: Biochemikalien
• Konjugation: Unconjugated

Produktbeschreibung

NSC636819 is a cell permeable and selective novel active-site KDM4A/KDM4B inhibitor with IC50 ~6.4 µM for KDM4A and 9.3 µM for KDM4B. It inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. It also negatively regulates androgen-responsive genes. The overexpression of KDM4A/KDM4B in prostate cancer and their association with androgen receptor suggest that KDM4A/KDM4B are potential progression factors for prostate cancer.

Produkteigenschaften

• Puffer: Powder
• CAS Nummer: [1618672-71-1]