Carnitine O octanoyltransferase, COT, CROT, OCTC_HUMAN, Peroxisomal carnitine acyltransferase, Peroxisomal carnitine O octanoyltransferase, Peroxisomal carnitine O-octanoyltransferase.
This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.
