Homeo box 2A, Homeo box B5, Homeobox 2A, Homeobox B5, Homeobox protein HHO.C10, Homeobox protein Hox B5, Homeobox protein Hox-2A, Homeobox protein Hox-B5, Homeobox protein HoxB5, Homeobox protein Hu-1, Homeobox2A, HomeoboxB5, HOX 2, Hox 2.1, HOX 2A, HOX B5, HOX2, Hox2.1, HOX2A, HOXB 5, Hoxb5, HU 1, HU1, HXB5_HUMAN.
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008].
