Epididymis luminal protein 210 antibody, Epididymis secretory protein Li 34 antibody, Epididymis secretory protein Li 96 antibody, HCNP antibody, HCNPpp antibody, HEL 210 antibody, HEL S 34 antibody, HEL S 96 antibody, Hippocampal cholinergic neurostimulating peptide antibody, Neuropolypeptide h3 antibody, PBP antibody, PEBP antibody, PEBP 1 antibody, PEBP-1 antibody, Pebp1 antibody, PEBP1_HUMAN antibody, Phosphatidylethanolamine binding protein antibody, Phosphatidylethanolamine binding protein 1 antibody, Prostatic binding protein antibody, Prostatic-binding protein antibody, R kip antibody, Raf kinase inhibitor protein antibody, Raf kinase inhibitory protein antibody, RKIP antibody
Phosphatidylethanolamine binding protein (PEBP), also known as Raf kinase inhibitory protein (RKIP) is a highly conserved multifunctional protein that modulates the Raf/MAPK signaling cascade and has been implicated as a suppressor of metastatic cancer (Trakul N et al., 2005). PEBP has been shown to not only inhibit cell proliferation but also to induce differentiation of human keratinocytes (Yamazaki et al., 2004). Dysregulation of calpain activity results in cellular degeneration in conditions such as Alzheimers disease and recently PEBP has been identified as a potential in vivo calpain substrate (Chen at al., 2006).
