Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p [1-4]. Displays higher activity in vivo than in vitro [1-4]. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket [5]. Shown to have diverse effects also in mammalian cells [6-10].
Puffer:
Solid
CAS Nummer:
[1384339]
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