Associated molecule with the SH3 domain of STAM, Endosome associated ubiquitin isopeptidase, Endosome-associated ubiquitin isopeptidase, STABP_HUMAN, STAM binding protein, STAM-binding protein, STAMBP.
Zinc metalloprotease that specifically cleaves Lys-63-linked polyubiquitin chains. Does not cleave Lys-48-linked polyubiquitin chains (By similarity). Functions at the endosome and is able to oppose the ubiquitin-dependent sorting of receptors to lysosomes. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7.
