Maternal inhibition of dferentiation, SECC 8, SSEC 8, CCDB1_HUMAN, CCNDBP 1, Ccndbp1, Cyclin D type binding protein 1, Cyclin-D1-binding protein 1, D type cyclin interacting protein 1, DIP 1, DIP1, GCIP, Grap 2 and cyclin D interacting protein, Grap 2 cyclin D interacting protein GCIP, Grap 2 cyclin interacting protein, Grap2 and cyclin D interacting protein, Grap2 and cyclin-D-interacting protein, Grap2 cyclin D interacting protein GCIP, Grap2 cyclin interacting protein, HHM protein, Human homolog of Maid, MAID, MAID protein, Stage specic embryonic cDNA 8.
May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.Tissue specificity: Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.
