G protein beta subunit like Antibody, Biotin Conjugated, Rabbit, Polyclonal
Artikelnummer:
BSS-BS-8161R-BIOTIN
Hersteller Artikelnummer:
bs-8161R-Biotin
Alternativnummer:
BSS-BS-8161R-BIOTIN-100
Hersteller:
Bioss
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
ELISA, IHC-Fr, IHC-P
Spezies Reaktivität:
Rat
Konjugation:
Biotin
Alternative Synonym:
G protein beta subunit like, G protein beta subunit-like, Gable, GBL, GBL protein, LST8_HUMAN, Mammalian lethal with SEC13 protein 8, MGC111011, mLST8, Protein GbetaL, Target of rapamycin complex subunit LST8, TORC subunit LST8.
Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at Thr-389, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.Tissue specificity:Broadly expressed, with highest levels in skeletal muscle, heart and kidney.
Klonalität:
Polyclonal
Konzentration:
1ug/ul
Puffer:
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Quelle:
KLH conjugated synthetic peptide derived from human G protein beta subunit like
