COX, COX VA, COX5A, COX5A_HUMAN, Cytochrome c oxidase polypeptide Va, Cytochrome c oxidase polypeptide, mitochondrial, Cytochrome c oxidase subunit 5A, Cytochrome c oxidase subunit 5A, mitochondrial, mitochondrial, Mitochondrial cytochrome c oxidase subunit Va, VA.
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. [provided by RefSeq, Jul 2008].
