C1ORF18, C1orf218, Chromosome 1 open reading frame 218, Connecdenn 2, DEN1B_HUMAN, DENN domain containing protein 1B, DENN domain-containing protein 1B, DENN MADD domain containing 1B, DENND1B, DKFZp547O0715, FAM31B, Family with sequence similarity 31 member B, FLJ20054, FLJ21179, FLJ33888, MGC103810, MGC27044, Protein FAM31B
Guanine nucleotide exchange factor (GEF) for RAB35. May function as a clathrin-associated sorting protein for RAB35, whereby during clathrin-mediated endocytosis, binds the AP-2 complex and inactived RAB35, then activates RAB35 for its subsequent function at endosomes.Tissue specificity:Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary. Significantly up-regulated in effector memory T cells as compared with naive T cells.
