Protein S Polyclonal Antibody, HRP Conjugated, Rabbit
Artikelnummer:
BSS-BS-9512R-HRP
Hersteller Artikelnummer:
bs-9512R-HRP
Alternativnummer:
BSS-BS-9512R-HRP-100,BSS-BS-9512R-HRP-20
Hersteller:
Bioss
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IHC-Fr, IHC-P, WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
HRP
Alternative Synonym:
Preproprotein S, Propiece of latent protein S, PROS 1, PROS, PROS_HUMAN, PROS1, Protein S alpha, Protein Sa, PS 21, PS 22, PS 23, PS 24, PS 25, PS 26, PS21, PS22, PS23, PS24, PS25, PS26, PSA, Vitamin K dependent protein S, Vitamin K-dependent protein S.
Protein S (PROS) is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated protein C (APC) and facilitates clearance of early apoptotic cells. In the plasma, circulating Protein S becomes inactive upon complexing with C4b-binding protein (C4BP), 60-70% of Protein S circulates in complex with C4BP. Calcium-dependent association of C4BP-Protein S with apoptotic cells influences the regulation of complement activation. Protein S has APC-independent anticoagulant activity through direct inhibition of prothrombin activation via interactions with Factor X A, Factor V A and phospholipids. Autosomal dominant Protein S deficiency (levels 15 to 37% of normal) correlates with severe recurrent venous thrombosis.
