DNA damage-regulated overexpressed in cancer 45 protein, DOC45, GBP45, GTP-binding protein 9 putative, GTP-binding protein 9, GTP-binding protein PTD004, homologous yeast-44.2 protein, Obg like ATPase 1, Obg-like ATPase 1, OLA1, OLA1_HUMAN, PTD004.
GTP-binding protein 9 is a 396 amino acid protein that belongs to the Obg-related GTPase family under the translation factors (TRAFAC) class. Originally thought to only have GTPase activity, Obg-related GTPase family members have been shown to also have ATPase activity. In Homo sapians, GTPBP9 exhibits a preference for binding ATP over GTP, with GTP binding occuring only at high nucleotide concentration. One cause for ATP affinity and GTP discrimination is thought to be a substitution of glutamine for a hydrophobic amino acid in Obg-related family members, this is the same substitution that inactivates Ras-like GTPases. GTPBP9 contains a C-terminal TGS domain that binds to ligands and an N-terminal G domain which binds nucleotides. GTPBP9 is expressed as three isoforms produced by alternative splicing.
