C3orf37, CC037_HUMAN, Chromosome 3 open reading frame 37, DC12, MGC111075, UPF0361 protein C3orf37.
C3orf37, also known as DC12 or MGC111075, is a 354 amino acid protein encoded by a gene that maps to human chromosome 3q21.3. Chromosome 3 is made up of approximately 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3.
