A type potassium channel modulatory protein 3, A-type potassium channel modulatory protein 3, Calsenilin, CSEN, CSEN_HUMAN, DRE antagonist modulator, DRE-antagonist modulator, DREAM, EF hand transcription factor, KCHIP 3, KCHIP3, KCNIP 3, KCNIP3, Kv channel interacting protein 3, Kv channel-interacting protein 3, MGC18289, Potassium channel interacting protein 3, Presenilin binding protein, R74849.
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
