Beclin 1 Monoclonal Antibody, PE Conjugated, Clone: [7B12], Mouse
Artikelnummer:
BSS-BSM-33323M-PE
Hersteller Artikelnummer:
bsm-33323M-PE
Alternativnummer:
BSS-BSM-33323M-PE-100
Hersteller:
Bioss
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IF, WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
PE
Alternative Synonym:
Beclin-1, BECN1, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197
Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate, different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense. Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis, it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
