Gracile axonal dystrophy, Neuron cytoplasmic protein 9.5, Park 5, Park5, Parkinson Disease 5, PGP 9.5, PGP9.5, PGP95, Protein gene product 9.5, Ubiquitin C terminal esterase L1, Ubiquitin C terminal hydrolase (neuron specific), Ubiquitin C terminal hydrolase, Ubiquitin carboxyl terminal esterase L1, Ubiquitin carboxyl terminal hydrolase isozyme L1, Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin thioesterase L1, Ubiquitin thiolesterase, Ubiquitin thiolesterase L1, UCH L1, UCH-L1, UCHL1, UCHL1_HUMAN.
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
