MLKL Recombinant Antibody, Unconjugated, Rabbit

Produktübersicht

• Artikelname: MLKL Recombinant Antibody, Unconjugated, Rabbit
• Artikelnummer: BSS-BSM-52256R
• Hersteller Artikelnummer: bsm-52256R
• Alternativnummer: BSS-BSM-52256R-100
• Hersteller: Bioss
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: WB
• Spezies Reaktivität: Human
• Konjugation: Unconjugated
• Alternative Synonym: Mixed lineage kinase domain-like protein, hMLKL, MLKL

Produktbeschreibung

Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610).

Produkteigenschaften

• Klonalität: Recombinant
• Konzentration: Lot dependent
• NCBI: 197259
• UniProt: Q8NB16
• Puffer: 0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol
• Quelle: Human MLKL between 350 to C-terminus
• Target-Kategorie: MLKL

Anwendungsbeschreibung

• Application Verdünnung: WB(1:300-5000)