4930429L08Rik antibody, 4933408A16 antibody, Alpha catenin like protein antibody, Alpha T catenin antibody, Alpha T-catenin antibody, Cadherin associated protein antibody, Cadherin-associated protein antibody, Catenin alpha 3 antibody, Catenin alpha-3 antibody, Catna3 antibody, CTNA3_HUMAN antibody, CTNNA3 antibody, MGC26194 antibody, MGC75041 antibody, OTTHUMP00000019684 antibody, OTTMUSP00000028119 antibody, OTTMUSP00000028120 antibody, RP11-433J16.1 antibody, VR22 antibody
The catenins are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. alpha T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantally expressed in cardiomyocytes and in the peritubular myoid cells of the testis. alpha T-catenin binds to alpha E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for alpha-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimers disease (LOAD) as well as to dilated cardiomyopathy.
