CDT 1, Chromatin licensing and DNA replication factor 1, Retroviral integration site 2, RIS2.
Required for both DNA replication and mitosis.DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC).