TRIM29 Recombinant Antibody, PE Conjugated, Rabbit
Artikelnummer:
BSS-BSM-62185R-PE
Hersteller Artikelnummer:
bsm-62185R-PE
Alternativnummer:
BSS-BSM-62185R-PE-100
Hersteller:
Bioss
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
PE
Alternative Synonym:
ATDC, TRIM29.
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its Lys-48 ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the Lys-48 ubiquitination of STING1 in a similar way, leading to its degradation.
