Inositol polyphosphate-5-phosphatase of 145 kDa, inositol polyphosphate-5-phosphatase, 145kDa, INPP5D, p150Ship,SHIP1.
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways.