A730008L03Rik antibody, AB041607 antibody, AI663983 antibody, Cofactor of BRCA1 antibody, DKFZp586B0519 antibody, KIAA1182 antibody, Negative elongation factor B antibody, Negative elongation factor protein B antibody, Nelf b antibody, NELF-B antibody, NELFB antibody, RGD1307832 antibody, RP13-122B23.3 antibody, RP23-132N23.4 antibody
COBRA1 (cofactor of BRCA1) also known as NELF-B, is an essential component of the negative elongation factor (NELF) complex. COBRA1 has been shown to directly bind estrogen receptor alpha (ERalpha) and repress ERalpha-mediated transcription (Aiyar SE et al., 2004). COBRA1 has also been demonstrated to interact with c-Jun and c-Fos suggesting a role in modulation of the AP-1 pathway and therefore may be important in cell proliferation, differentiation, apoptosis and oncogenesis (Zhong H et al., 2004)
