DBCN antibody, Dbct antibody, DC antibody, DCX antibody, DCX_HUMAN antibody, Doublecortex antibody, Doublin antibody, FLJ51296 antibody, Lis X antibody, Lis-X antibody, Lissencephalin X antibody, Lissencephalin-X antibody, Lissencephaly X linked antibody, Lissencephaly X linked doublecortin antibody, LISX antibody, Neuronal migration protein doublecortin antibody, OTTHUMP00000023859 antibody, OTTHUMP00000023860 antibody, OTTHUMP00000216315 antibody, OTTHUMP00000216316 antibody, SCLH antibody, XLIS antibody
Doublecortin, or DCX, is a microtubule associated protein that is expressed almost exclusively in very early neuronal development (Brown et al., 2003), making it an excellent marker for developing neuronal cells. Defects in the DCX gene lead to X-linked lissencephaly which is characterized by a lack of normal folds on the surface of the brain resulting in a smooth cerebral cortex caused by abnormal migration of neurons during development (des Portes et al., 1998, Gleeson et al., 1998).
